Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Migraine Age: Adult: greater than 18 years |
Dose: Oral – 50-100 mg Frequency: repeated at 2-hour intervals if migraine recurs Note: Maximum: 200 mg/24 hours |
|
Indication: Migraine Age: Adult: greater than 18 years Condition: Mild to moderate hepatic impairment |
Dose: Oral – 50 mg Note: Maximum single dose: 50 mg |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Dose: Note: Safety and efficacy not established |
Administration
- Can be taken with or without food
- Take at first sign of migraine
Side Effect
- Injection site reaction (Less than 86%)
- Paresthesia (5-14%)
- Dizziness (12%)
- Warm/hot sensation (11%)
- Chest discomfort/pressure/tightness (2-5%)
- Jaw or neck tightness (1-5%)
- Diaphoresis (2%)
- Burning sensation (7%)
- Cold sensation (1%)
- Dysphagia
- Sore throat (3%)
- Malaise (1%)
- Abdominal distress (1%)
- Agitation
- Cardiac arrhythmia V-fib/V-tach (rare)
- Dysuria
- Eye irritation
- Flushing
- MI and coronary artery vasospasm in patients with CAD risk factors (extremely rare)
- Nasal discomfort
- Palpitations
- Tingling
- Weakness
- Cardiac arrhythmias
- MI
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ergotamine and related compounds
|
Increased risk of vasospastic reaction
|
|
SSRI, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide)
|
Increased risk of serotonin syndrome
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Basilar/Hemiplegic/Ophthalmoplegic Migraine
|
Can cause dangerous complications
|
|
History of MI/Stroke
|
Risk of cardiovascular events
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20°C-25°C temperature. Do not store in the refrigerator or freezer. Do not test before use
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.