Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Breast Cancer Treatment Age: Adult |
Dose: Oral – 20 mg Frequency: daily as a single or in 2 divided doses Duration: at least 5 years Note: Maximum: 40 mg daily. Continue with adjuvant therapy for at least 5 years. For women with estrogen receptor-positive disease, continuing tamoxifen to 10 years rather than stopping at 5 years produces a further reduction in recurrence and mortality, particularly after year 10. |
|
Indication: Breast Cancer Prevention Age: Adult Condition: High risk (aged greater than 35 years with a 5-year predicted risk of breast cancer greater than 1.67% calculated by the Gail Model) |
Dose: Oral – 20 mg Frequency: once daily Duration: 5 years Note: Data are limited for use greater than 5 years in the risk-reduction setting. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: McCune-Albright Syndrome and precocious puberty Age: Girls 2 to 10 years |
Dose: Tablet – 20 mg Frequency: once daily Note: by mouth (oral) |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Hot flashes (64%)
- Vaginal discharge (30%)
- Amenorrhea (16%)
- Menstrual changes (13%)
- Oligomenorrhea (9%)
- Cataracts (8%)
- Bone pain (6%)
- Nausea (5%)
- Cough (4%)
- Edema (4%)
- Fatigue (4%)
- Musculoskeletal pain (3%)
- Ovarian cyst (3%)
- Depression (2%)
- Abdominal cramps (1%)
- Anorexia (1%)
- Angioedema
- Corneal changes
- Loss of libido
- Endometrial cancer
- Pancreatitis
- Retinal vein thrombosis
- Stroke
- Uterine fibroids
- Blood dyscrasias
- cholestasis
- hepatitis
- hypercalcaemia in patients with bone metastasis
- thromboembolic events
- Increased risk of endometrial cancer and uterine sarcoma
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Bromocriptine
|
Increases dopaminergic effect
|
|
Cytotoxic drugs
|
Increased risk of thromboembolic events
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of DVT/Pulmonary Embolism
|
Risk of blood clots
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.