Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – 25-50 mg/day initially Note: May be increased to 100 mg/day |
|
Indication: Angina Pectoris Age: Adult |
Dose: Oral – 50 mg/day Duration: 1 week Note: After 1 week, may be increased to 100 mg/day; some patients may require 200 mg/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment: Creatinine Clearance less than 15 ml/min |
Dose: Tablet – 25 mg or 50 mg Frequency: on alternate days |
|
Age: Adult Condition: Renal impairment: Creatinine Clearance 15-35 ml/min |
Dose: Tablet – 50 mg Frequency: once daily |
Administration
- Take with or without food
- Take at same time daily
Side Effect
- Tiredness (13%)
- Hypotension (10%)
- Bradycardia (8%)
- Cold extremities (0.5- 7%)
- Postural hypotension (2-4%)
- Depression (3%)
- Nausea (2-3%)
- Dreaming (2%)
- Drowsiness (2%)
- Diarrhea (1-2%)
- Fatigue (1-2%)
- Leg pain (1-2%)
- Lethargy (1-2%)
- Lightheadedness (1-2%)
- Vertigo (1-2%)
- Dyspnea (0.4-2%)
- 2°/3° atrioventricular (AV) block (1%)
- Hypotension
- severe congestive heart failure (CHF)
- sick sinus syndrome
- Catatonia
- disorientation
- emotional lability
- hallucinations
- headache
- impaired performance on neuropsychometric tests
- psychoses
- short-term memory impairment
- Purpura
- rashes
- Nausea
- Thrombocytopenia
- Elevated serum hepatic enzymes and bilirubin
- Impotence
- Peyronie disease
- Antinuclear antibodies (ANA)
- lupus syndrome
- Visual disturbances
- xerophthalmia
- Raynaud phenomenon
- Heart failure
- 2nd or 3rd degree AV block
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Reserpine
|
May increase hypotension and bradycardia
|
|
Ca channel blockers, hydralazine, methyldopa
|
Additive effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Sinus Bradycardia, Sinus Node Dysfunction
|
Can cause dangerous heart rate reduction
|
|
Heart Block >1st Degree, Compensated Cardiac Failure
|
Can worsen heart conduction problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.