Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Oral – 30–50 mg/kg/day Frequency: every 8 hours |
|
Indication: Amoebiasis Age: Adult Condition: intestinal infection |
Dose: Oral – 800 mg Frequency: three times daily Duration: 5 days Note: Maximum dose: 2.4 g/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Amoebiasis Age: Child: 1-3 years |
Dose: Oral – 100-200 mg Frequency: three times daily Duration: 5-10 days |
|
Indication: Amoebiasis Age: Child: greater than 3-7 years |
Dose: Oral – 100-200 mg Frequency: 4 times daily Duration: 5-10 days |
Administration
- Suspension: Take on empty stomach 1 hour before meals
- Tablets: Take with food
Side Effect
- GI disturbances eg nausea
- unpleasant metallic taste
- vomiting
- diarrhoea or constipation
- Furred tongue
- glossitis
- and stomatitis due to overgrowth of Candida
- Rarely
- antibiotic-associated colitis
- Weakness
- dizziness
- ataxia
- headache
- drowsiness
- insomnia
- changes in mood or mental state
- Numbness or tingling in the extremities
- epileptiform seizures (high doses or prolonged treatment)
- Transient leucopenia and thrombocytopenia
- Hypersensitivity reactions
- Urethral discomfort and darkening of urine
- Raised liver enzyme values
- cholestatic hepatitis
- jaundice
- Thrombophlebitis (IV)
- Anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Disulfiram
|
May produce psychotic reactions
|
|
Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May potentiate the effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.