Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Infections Caused by Susceptible Organisms Age: Adult Condition: Uncomplicated |
Dose: Intravenous or Intramuscular – 1 g Frequency: every 12 hours |
|
Indication: Infections Caused by Susceptible Organisms Age: Adult Condition: Moderate to severe |
Dose: Intravenous or Intramuscular – 1-2 g Frequency: every 8 hours |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Children |
Dose: Intravenous or Intramuscular – 50–180 mg/kg/day Frequency: every 6–8 hours |
|
Indication: Meningitis Age: Children |
Dose: Intravenous or Intramuscular – 200–225 mg/kg/day Frequency: every 6 hours |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Severe |
Dose: Not specified – 1 g Frequency: once Note: Initial loading dose |
|
Condition: Renal impairment: Severe |
Dose: Not specified – half the daily dose Frequency: without changing the frequency Note: Maintenance dose following an initial loading dose of 1 g |
Administration
- For hospital use only
- Must be given by injection
Side Effect
- Colitis
- Elevated blood urea nitrogen (BUN) and creatinine
- Elevated hepatic transaminases
- Fever
- Pain at Injection site
- hypersensitivity reactions
- rash
- pruritus
- diarrhoea
- nausea
- vomiting
- candidiasis
- eosinophilia
- neutropenia
- leucopenia
- thrombocytopenia
- Anaphylactic reaction
- nephrotoxicity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid
|
Decreases cefotaxime elimination
|
|
Furosemide, Aminoglycosides
|
Nephrotoxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for allergic reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25°C, protected from light and moisture. Use reconstituted solution immediately. Reconstituted solution is stable for up to 24 h if stored between 2° to 8°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.