Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Induction of anesthesia Age: Adult |
Dose: Intravenous injection – 100-150 mg of a 2.5 or 5% solution Frequency: injected over 10-15 seconds repeated every 30-60 seconds according to response Note: Max: 500mg. Max in pregnancy: 250mg. |
|
Indication: Induction of anesthesia Age: Adult |
Dose: Continuous infusion – 0.2 or 0.4% solution Note: Max: 500mg. Max in pregnancy: 250mg. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Induction of anesthesia Age: Child |
Dose: Intravenous – 2-7 mg/kg Duration: over 10-15 seconds Note: repeated after 1 minute if needed |
|
Indication: Status epilepticus Age: Child |
Dose: Intravenous injection – 5 mg/kg Note: by slow intravenous injection followed by a continuous intravenous infusion |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: - Note: Dose reduction may be needed |
Administration
- For hospital use only
- Must be administered by healthcare professionals
Side Effect
- Coughing
- hiccupping
- sneezing
- muscle twitching
- laryngospasm
- bronchospasm
- IV tissue necrosis (if extravasation occurs)
- Intra-arterial Severe arterial spasm with burning pain
- blanching of forearm and hands and gangrene of digits
- Respiratory depression
- arrhythmias
- circulatory failure and anaphylactoid reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Alcohol, CNS depressants
|
Possible increase in difficulty in producing anaesthesia
|
|
Sedatives, hypnotics, nitrous oxide, alcohol
|
Additive action with other CNS depressants
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Respiratory Embarrassment
|
Can cause respiratory failure
|
|
Status Asthmaticus
|
Risk of respiratory arrest
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at controlled room temperature of 15° C to 30° C. Solutions should be freshly prepared and used immediately. Any portion of the contents remaining should be discarded.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.