Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: Adult
Dose: Oral Tablet – 50 mg atenolol/25 mg chlorthalidone
Frequency: once daily
Note: Initial dose; not indicated for initial therapy; if the fixed dose combination represents the dose appropriate to the individual patient's needs, it may be more convenient than the separate components.
Indication: Hypertension
Age: Adult
Dose: Oral Tablet – 100 mg atenolol/25 mg chlorthalidone
Frequency: once daily
Note: May increase to this dose if needed; when necessary, another antihypertensive agent may be added gradually beginning with 50 percent of the usual recommended starting dose to avoid an excessive fall in blood pressure.

Child Dose

Clinical InformationAdministration Information
Age: Pediatric
Dose: Form – No approved pediatric dosage available
Note: No approved pediatric dosage available

Renal Dose

Clinical InformationAdministration Information
Condition: Creatinine Clearance greater than 35 mL/minute/1.73 m²
Dose: Tablet – Dosage not specified
Note: Use caution in dosing or titrating patients with renal dysfunction. Cumulative effects of thiazides may develop with impaired renal function. Dose adjustment not necessary.
Condition: Creatinine Clearance 15-35 mL/minute/1.73 m²
Dose: Tablet – Maximum 50 mg
Frequency: once daily
Note: by mouth (oral). Use caution in dosing or titrating patients with renal dysfunction. Cumulative effects of thiazides may develop with impaired renal function.
Administration
  • Take with food
  • Take in morning
Side Effect

Drug Interaction

Drug NameRisk Factors
Reserpine
May increase hypotension and bradycardia
Ca channel blockers, hydralazine, methyldopa
Additive effects

Disease Interaction

Disease NameRisk Factors
Sinus Bradycardia
Can cause dangerous heart rate reduction
2nd or 3rd Degree Heart Block
Can worsen heart block

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in cool and dry place, protected from light.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.