Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is a thrombolytic agent. It helps to break down blood clots. It is used to treat heart attacks, strokes, and pulmonary embolisms.

Question 2

When and how should this medicine be taken?

Accepted Answer

• For hospital use only • Must be administered by healthcare professional • Requires careful monitoring

Question 3

When should this medicine not be used?

Accepted Answer

• In active bleeding • After recent surgery • In severe hypertension

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Use under close medical supervision • Risk of bleeding • Not for use in recent surgery

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Not safe during pregnancy; • May cause placental abruption; • Use only if clearly needed

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Use under close medical supervision • Risk of bleeding • Not for use in recent surgery

Question 7

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For once-daily dosing: If you remember on the same day, take the dose. • For twice-daily dosing: If more than 8 hours until your next dose, take the missed dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 8

What should be done in case of an overdose?

Accepted Answer

• Overdose symptoms: Risk of hemorrhage, bleeding. • Treatment: Antifibrinolytic agents, control bleeding.

Question 9

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Bleeding, fever, blood in urine, allergic reactions • What to do: Close monitoring required; Report unusual bleeding; Check vital signs regularly; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 10

What medical indications are treated with Urokinase?

Accepted Answer

Urokinase (Fibrinolytics (Thrombolytics)) is a pharmaceutical active substance. It is indicated for the treatment of Acute Myocardial Infarction (MI), Deep Vein Thrombosis (DVT), Pulmonary Embolism, Thromboembolism.

Question 11

What is the recommended dosage for Urokinase?

Accepted Answer

Standard adult dosage: Intravenous – 4400 units/kg (Initially, infused over 10 minutes followed by 4400 units/kg/hr). Pediatric dosage: Intravenous infusion via central venous line – 2,500 units per lumen (as required). Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 12

Is Urokinase safe during pregnancy and breastfeeding?

Accepted Answer

Urokinase is classified under Pregnancy Category "B". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 13

What are the common side effects of Urokinase?

Accepted Answer

Bleeding; pyrexia; haematuria; thromboembolic episodes; hypersensitivity reactions; **Potentially Fatal**; Severe bleeding; anaphylaxis;

Clinical Information	Administration Information
Indication: Deep vein thrombosis Age: Adult	Dose: Intravenous – 4400 units/kg Frequency: Initially, infused over 10 minutes followed by 4400 units/kg/hr Duration: 12-24 hours Note: Dissolved in 15 ml of sodium chloride 0.9%
Indication: Acute myocardial infarction Age: Adult	Dose: Parenteral – 6000 units/minute Frequency: Infused into the coronary artery Duration: 2 hours Note: Preceded by intravenous heparin

Clinical Information	Administration Information
Indication: Infusion into central venous line and line lock Age: Child	Dose: Intravenous infusion via central venous line – 2,500 units per lumen Frequency: as required
Indication: Infusion into central venous line and line lock Age: Child	Dose: Intravenous infusion via central venous line – 5,000 units per lumen Frequency: as required

Drug Name	Risk Factors
Antibodies	Reduced thrombolytic effect when given again some time later due to development of high levels of antibodies
Platelet inhibitors (e.g. aspirin, indometacin)	Potentially Fatal: Can potentiate the action of urokinase and cause haemorrhage

Disease Name	Risk Factors
Active Internal Bleeding	Can increase bleeding severity
Recent Cerebrovascular Accident	Risk of new bleeding

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources