Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult Condition: Immediate release |
Dose: Oral – 80 mg Frequency: initially every 8 hours Note: maintenance: 80-320 mg by mouth every 12 hours |
|
Indication: Hypertension Age: Adult Condition: Extended release |
Dose: Oral – 180 mg per day Note: 120 mg per day initially if patient elderly or of small stature; for desired response, may be increased to 240 mg per day by mouth, then by 120 mg per day at weekly intervals; not to exceed 480 mg per day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Supraventricular Tachycardia Age: 1-15 years old |
Dose: Intravenous – 0.1-0.3 mg/kg Duration: over 2 minutes Note: not to exceed 5 mg; second dose (not to exceed 10 mg) may be given after 30 minutes |
|
Indication: Supraventricular Tachycardia Age: 1-15 years old |
Dose: Oral – 4-8 mg/kg/day Frequency: divided every 8 hours Note: by mouth (oral); not well established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet/Capsule, extended release – 100 mg Frequency: once daily at bedtime Note: For Verelan PM, manufacturer recommends 100 mg at bedtime initially; use with caution and monitor electrocardiogram |
|
Condition: Renal impairment with Creatinine Clearance less than 10 mL/minute |
Dose: Tablet/Capsule, extended release – Dosage reduced by 25-50% Note: Use with caution and monitor electrocardiogram |
Administration
- Should be taken with food
- Take at regular intervals
Side Effect
- Headache
- Gingival hyperplasia
- Constipation (9%)
- Dizziness (4%)
- Hypotension (4%)
- Dyspepsia (3%)
- Nausea (3%)
- Edema (2%)
- Rash (2%)
- Increased liver enzymes (1%)
- Sleep disturbance (1%)
- Dyspnea
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol), flecainide
|
Increased cardiac depressant effects
|
|
Digoxin
|
Increased risk of additive bradycardia, conduction disturbances and digoxin toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Cardiogenic Shock
|
Can worsen heart failure
|
|
Hypotension
|
Can dangerously lower blood pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.