Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV Infection |
Dose: Tablet – 300 mg Frequency: every 12 hours Note: (600 mg/day) |
|
Indication: HIV Infection |
Dose: Tablet – 200 mg Frequency: every 8 hours Note: (600 mg/day) |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV Infection, Treatment Age: 4 weeks-18 years |
Dose: Oral – 240 mg/m² Frequency: every 12 hours Note: by mouth (oral) |
|
Indication: HIV Infection, Treatment Age: 4 weeks-18 years |
Dose: Oral – 160 mg/m² Frequency: every 8 hours Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment CrCl less than 15 mL/min (maintained on hemodialysis or peritoneal dialysis) |
Dose: Tablet – 100 mg Frequency: every 6-8 hours Note: administered by mouth (oral) |
|
Condition: Renal Impairment CrCl less than 15 mL/min (maintained on hemodialysis or peritoneal dialysis) |
Dose: Injection – 1 mg/kg Frequency: every 6-8 hours Note: administered intravenous |
Administration
- Can be taken with or without food
- Take exactly as prescribed
Side Effect
- Anemia (23% in children)
- Anorexia (11%)
- Diarrhea (17%)
- Fever (16%)
- Granulocytopenia (39% in children)
- Headache
- severe (42%)
- Leukopenia (39%)
- Nausea (46-61%)
- Pain (20%)
- Rash (17%)
- Vomiting (6-25%)
- Weakness (19%)
- Malaise (8%)
- Dizziness (6%)
- Insomnia (5%)
- Somnolence (8%)
- Hyperpigmentation of nails (bluish-brown)
- Dyspepsia (5%)
- Changes in platelet count
- Paresthesia (6%)
- Lactic acidosis
- severe hepatomegaly with steatosis
- hepatotoxicity
- Blood dyscrasias
- eg serious anaemia (may require transfusion)
- neutropenia
- leucopenia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Tipranavir
|
Decreased zidovudine concentration
|
|
Bortezomib
|
Increased risk of peripheral neuropathy
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Abnormally Low Neutrophil Counts
|
Risk of severe infections
|
|
Low Hemoglobin Levels
|
Risk of severe anemia
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.