Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Antisialagogue or for antivagal effects Age: Adult |
Dose: Injection – 0.5 mg to 1 mg Frequency: initial single dose |
|
Indication: Antidote for organophosphorus or muscarinic mushroom poisoning Age: Adult |
Dose: Injection – 2 mg to 3 mg Frequency: repeated every 20-30 minutes Note: Initial single dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Anesthesia Premedication |
Dose: Dose – 0.02 mg/kg/dose Frequency: 30-60 minutes preoperatively; then every 4-6 hours as needed |
|
Indication: Anesthesia Premedication |
Dose: intravenous/intramuscular/subcutaneous – 0.01-0.02 mg/kg Note: no more than 0.4 mg |
Administration
- Take with food
- Take with water
Side Effect
- Dry mouth
- dysphagia
- constipation
- flushing and dryness of skin
- tachycardia
- palpitations
- arrhythmias
- mydriasis
- photophobia
- cycloplegia
- raised intraocular pressure
- Toxic doses cause tachycardia
- hyperpyrexia
- restlessness
- confusion
- excitement
- hallucinations
- delirium and may progress to circulatory failure and resp depression
- Dryness of mouth, throat
- Atrial arrhythmias
- AV dissociation
- multiple ventricular ectopics
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Quinidine, Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Some Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin)
|
Additive anticholinergic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Glaucoma
|
Can increase eye pressure dangerously
|
|
Chronic Respiratory Disease
|
Can worsen breathing difficulties
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store atropine at room temperature between 20 to 25° C. Store away from heat, moisture, and light. Keep atropine out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.