Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type I or II Diabetes Mellitus Age: Adult |
Dose: Subcutaneous – Dosage based on blood glucose measurements Frequency: once daily Note: Administer with evening meal or at bedtime. Adjust to achieve appropriate glucose control. Look for consistent pattern in blood sugars for greater than 3 days. |
|
Indication: Type I or II Diabetes Mellitus Age: Adult |
Dose: Subcutaneous – Dosage based on blood glucose measurements Frequency: twice daily Note: Administer with morning meal and either with evening meal, at bedtime, or 12 hours after the morning dose. Adjust to achieve appropriate glucose control. Look for consistent pattern in blood sugars for greater than 3 days. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 1 Diabetes Mellitus Age: less than 2 years |
Dose: Subcutaneous – dose not established Note: Safety and efficacy not established |
|
Indication: Type 1 Diabetes Mellitus Age: greater than 2 years |
Dose: Subcutaneous – Approximately one-third of the total daily insulin requirements Note: Subcutaneous; rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirements; usual daily maintenance range in adolescents is less than 1.2 units/kg/day during growth spurts |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Renal Dose – Dose adjustments may be needed Note: Renal impairment: Dose adjustments may be needed. |
Administration
- Can be taken with or without food
- Give at bedtime if once daily
Side Effect
- Hypoglycaemia
- lipodystrophy
- pruritus
- rash
- weight gain
- sodium retention and oedema
- Injection site reactions eg pain
- itching
- hives
- swelling and inflammation
- Influenza-like symptoms
- Pallor
- Palpitation
- Tachycardia
- Mental confusion
- Weakness
- Blurred vision
- Itching
- Hunger
- Nausea
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol)
|
Possible absence of hypoglycaemic warning symptoms
|
|
Thiazide diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone), corticosteriods, chlorpromazine, tibolone, isoniazid, niacin, some calcium-channel blockers (diltiazem, nifedipine), diazoxide, lithium, thyroid hormones
|
Increased blood sugar
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Contraindicated routes
|
Wrong administration can be dangerous
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Unused (unopened) Insulin Detemir should be stored in the refrigerator between 2° and 8°C. Do not store in the freezer or directly adjacent to the refrigerator cooling element. Do not freeze. Do not use Insulin Detemir if it has been frozen. Unused (unopened) Insulin Detemir can be kept until the expiration date printed on the label if it is stored in a refrigerator. Keep unused Insulin Detemir in the carton so that it stays clean and protected from light.
If refrigeration is not possible, unused (unopened) Insulin Detemir can be kept unrefrigerated at room temperature, below 30°C as long as it is kept as cool as possible and away from direct heat and light. Unrefrigerated Insulin Detemir should be discarded 42 days after it is first kept out of the refrigerator, even if the FlexPen or vial still contains insulin.
If refrigeration is not possible, unused (unopened) Insulin Detemir can be kept unrefrigerated at room temperature, below 30°C as long as it is kept as cool as possible and away from direct heat and light. Unrefrigerated Insulin Detemir should be discarded 42 days after it is first kept out of the refrigerator, even if the FlexPen or vial still contains insulin.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.