Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chemotherapy-induced neutropenia, Myelosuppressive Chemotherapy Adjunct Age: Adult Condition: Non-myeloid malignancies receiving myelosuppressive chemotherapy associated with febrile neutropenia |
Dose: Subcutaneous Injection – 6 mg Frequency: single dose for each chemotherapy cycle Note: Indicated to decrease incidence of infection; given at least 24 hours after cytotoxic chemotherapy. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevention of Chemotherapy Induced Neutropenia Age: Pediatric |
Dose: Subcutaneous – 100 mcg/kg Frequency: once per chemotherapy cycle Note: not to exceed 6 mg/dose; do not administer in the period 14 days before and 24-72 hr after administration of cytotoxic chemotherapy |
|
Indication: Prevention of Chemotherapy Induced Neutropenia Age: Pediatric |
Dose: Subcutaneous – 6 mg Frequency: once per chemotherapy cycle Note: do not administer in the period 14 days before and 24 hr after administration of cytotoxic chemotherapy |
Administration
- Give as subcutaneous injection
- Use once per chemotherapy cycle
Side Effect
- Peripheral edema (12%)
- Asthenia (13%)
- Headache (16%)
- Vomiting (13%)
- Bone pain (31-57%)
- Myalgia (21%)
- Weakness (13%)
- Alopecia (15-72%)
- Pyrexia (23%)
- Acute respiratory distress syndrome
- Sickle cell crisis
- Splenic rupture
- Hyperuricemia
- Elevated lactate dehydrogenase
- Elevated alkaline phosphatase
- Allergic reaction
- Anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cytotoxic chemotherapy
|
Should not be given at the same time due to the increased risk of myelosuppression
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Severe allergic reaction risk
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Pegfilgrastim should be stored at 2-8° C & avoid shaking before injection. Don’t store it at room temperature for more than 48 hours. Do not administer this product if discoloration or particulates are observed.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.