Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Neovascular (wet) age-related macular degeneration Age: Adult |
Dose: Intravitreal Injection – 0.5 mg (0.05 mL of 10 mg/mL) Frequency: monthly Note: Continue treatment until visual acuity is stable for 3 consecutive months. Doses are given at intervals of at least 1 month. |
|
Indication: Macular oedema secondary to retinal vein occlusion Age: Adult |
Dose: Intravitreal Injection – 0.5 mg Frequency: monthly Duration: 6 months Note: Doses are given at intervals of at least 1 month. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Retinopathy of prematurity Age: Preterm infants |
Dose: Intravitreal injection – 0.2 mg Frequency: Single injection per eye Note: up to three injections per eye may be administered within six months of treatment initiation |
Administration
- For intravitreal injection only
- Must be administered by qualified healthcare provider
Side Effect
- Conjunctival hemorrhage (43-77%)
- Eye pain (17-37%)
- Vitreous floaters (3-32%)
- Incr IOP (8-24%)
- Vitreous detachment (7-22%)
- Eye irritation (4-19%)
- Intraocular inflammation (5-18%)
- Headache (2-15%)
- Upper resp tract infection (2-15%)
- Retinal disorder (13%)
- Blepharitis (3-13%)
- Retinal degeneration (1-11%)
- Conjunctival hyperemia (9%)
- Posterior capsule opacification (8%)
- Injection site hemorrhage (5%)
- Vitreous hemorrhage (4%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Belimumab
|
May enhance the adverse/toxic effect
|
|
Verteporfin photodynamic therapy (PDT)
|
Serious intraocular inflammation may occur when used adjunctively
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active ocular infection
|
Can worsen infection
|
|
Active severe intraocular inflammation
|
Risk of complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 2-8° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.