Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Relapsed or refractory low-grade or follicular, CD20-positive, B-cell Non-Hodgkin Lymphoma |
Dose: Intravenous infusion – 375 mg/m² Frequency: Once weekly Duration: 4 to 8 doses |
|
Indication: Retreatment for relapsed or refractory, low-grade or follicular, CD20-positive, B-cell Non-Hodgkin Lymphoma |
Dose: Intravenous infusion – 375 mg/m² Frequency: Once weekly Duration: 4 doses |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not applicable – Safety and efficacy not established Note: Safety and efficacy not established |
Administration
- Given as IV infusion only
- First dose: start slow, increase gradually
Side Effect
- Angioedema (11%)
- hypotension (10%)
- Asthenia (26%)
- chills (33%)
- dizziness (10%)
- fever (53%)
- headache (19%) Pruritus (14%)
- rash (15%)
- Abdominal pain (14%)
- diarrhea (10%)
- nausea (23%)
- vomiting (10%) Leukopenia (14%)
- lymphopenia (48%)
- neutropenia (14%)
- thrombocytopenia (12%)
- Back pain (10%)
- myalgia (10%) Cough (13%)
- rhinitis (12%)
- Infection (31%)
- night sweats (15%)
- Edema
- Flushing
- Hypertension
- Anxiety
- Anemia
- Elevated LDH
- Hyperglycemia
- Bronchospasm
- dyspnea
- sinusitis
- throat irritation
- urticaria
- RA (Rituximab+Methotrexate vs Methotrexate Alone)
- Hypertension
- Anxiety
- asthenia
- chills
- migraine
- paresthesia
- pyrexia
- Pruritus
- urticaria
- Dyspepsia
- nausea
- upper abd pain
- Hypercholesterolemia
- Arthralgia
- Rhinitis
- throat irritation
- URI
- Tumor lysis syndrome
- Lymphoid malignancies
- Hypogammaglobulinemia
- Pulmonary or cardiac toxicity during infusion
- severe mucocutaneous reactions
- severe cytokine release syndrome associated with tumor lysis syndrome
- Toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cisplatin
|
Increased risk of renal toxicity
|
|
Live vaccines
|
Potentially Fatal: May decrease the efficacy of vaccines and increase the risk of infections
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Type I Hypersensitivity to Murine Proteins
|
Can cause severe allergic reactions to mouse-derived proteins
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 2-8° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.