Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute exacerbations of chronic bronchitis; Acute otitis media; Urinary tract infections Age: Adult |
Dose: Intravenous – 960 mg Frequency: twice daily Note: Severe hepatic impairment: Contraindicated. |
|
Indication: Severe infections Age: Adult |
Dose: Intravenous – 2.88 g daily Frequency: in 2 divided doses Note: Severe hepatic impairment: Contraindicated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute exacerbations of chronic bronchitis; Acute otitis media; Urinary tract infections Age: Child |
Dose: Intravenous – 18 mg/kg Frequency: every 12 hours Note: Acute exacerbations of chronic bronchitis; Acute otitis media; Urinary tract infections |
|
Indication: Acute exacerbations of chronic bronchitis; Acute otitis media; Urinary tract infections Age: Child Condition: Severe infections |
Dose: Intravenous – Up to 27 mg/kg Frequency: every 12 hours Note: Maximum: 1.44 g every 12 hours |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance less than 15 ml/min |
Dose: Dosage Recommendation – Not recommended. Note: Renal impairment: Creatinine Clearance (ml/min) Dosage Recommendation |
|
Condition: Renal impairment: Creatinine Clearance 15-30 ml/min |
Dose: Dosage Recommendation – Half the standard dose. Note: Renal impairment: Creatinine Clearance (ml/min) Dosage Recommendation |
Administration
- Dilute each 5mL in 125mL dextrose
- For fluid restricted patients use 75mL
Side Effect
- Allergic myocarditis
- erythema multiforme
- exfoliative dermatitis
- angioedema
- drug fever
- chills
- Henoch-Schoenlein purpura
- serum sickness-like syndrome
- generalised allergic reactions
- generalised skin eruptions
- photosensitivity
- conjunctival and scleral inj
- pruritus
- urticaria
- rash
- periarteritis nodosa
- SLE
- elevated serum transaminase and bilirubin
- pseudomembranous enterocolitis
- pancreatitis
- stomatitis
- glossitis
- nausea
- emesis
- abdominal pain
- diarrhoea
- anorexia
- renal failure
- interstitial nephritis
- elevated BUN and serum creatinineeatinine
- toxic nephrosis w/ oliguria and anuria
- hyperkalaemia
- aseptic meningitis
- convulsions
- peripheral neuritis
- ataxia
- vertigo
- tinnitus
- headache
- hallucinations
- depression
- apathy
- nervousness
- dieresis
- hypoglycaemia
- arthralgia
- myalgia
- rhabdomyolysis
- cough
- shortness of breath
- pulmonary infiltrates
- weakness
- fatigue
- insomnia
- QT prolongation
- haemolysis
- impaired phenylalanine metabolism
- Severe skin
- hepatic and blood disorders
- aplastic anaemia
- hypersensitivity of the resp tract
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- Clostridium difficile-associated diarrhoea
- severe and symptomatic hyponatraemia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril)
|
May increase risk of hyperkalaemia
|
|
Prilocaine
|
Increased risk of methaemoglobinaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Failure
|
Risk of drug toxicity
|
|
Serious Haematological Disorders
|
Risk of blood disorders
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.