Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prophylaxis of tetanus Condition: Injury, non-immune or partially immune persons |
Dose: Injection – 3,000 to 5,000 units Note: Administered subcutaneously or intramuscularly. Active immunization with Adsorbed Tetanus vaccine should be given simultaneously or a booster injection given if previously immunized. |
|
Indication: Prophylaxis of tetanus Condition: Crush wounds or wounds contaminated with soil or other foreign bodies |
Dose: Injection – 10,000 to 20,000 units Note: Administered subcutaneously or intramuscularly. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevention of tetanus in wound management Age: Child |
Dose: Intramuscular – 1500 IU; 3000 IU if more than 24 hours has elapsed Frequency: Single dose |
|
Indication: Treatment of tetanus Age: Neonate |
Dose: Intramuscular – 1500 IU Frequency: Single dose |
Administration
- Given by IM or SC injection
- Test dose may be required
Side Effect
- Reactions are liable to occur after the injection of any serum of animal origin
- Anaphylaxis may occur in rare cases
- with hypotension
- dyspnoea
- urticaria
- and shock
- Anaphylactic reactions should be treated with adrenalin, possibly in association with antihistamine and corticosteroid therapy
- Serum sickness may occur 7 to 10 days after injection of serum of animal origin
- fever
- vomiting
- diarrhoea
- bronchospasm
- and urticaria
- nephritis
- myocarditis
- neuritis
- polyarthritis and uveitis have been reported as rare complications of serum sickness
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Immunosuppressants (Cyclosporine, Tacrolimus, Mycophenolate, Azathioprine)
|
Decreased immunologic response
|
|
Tetanus immune globulin, Tetanus toxoid adsorbed
|
Neutralisation if not given at different sites using different syringes
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Asthma
|
Risk of severe allergic reaction
|
|
Infantile Eczema
|
Risk of skin reaction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep out of the reach and sight of children. Store at +2°C to +8°C. Transportation should also be at +2°C to +8 °C. Do not freeze. Discard solution if frozen. Protect from light
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.