Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia Age: Adult |
Dose: Oral – Initially, 50-100 mg Frequency: three times daily Note: Gradually increased if necessary in increments of not more than 100 mg weekly. Usual daily dose: 200-800 mg in 2-4 divided doses. Maximum: 800 mg daily. |
|
Indication: Depressive Disorders Age: Adult |
Dose: Oral – Initially, 25 mg Frequency: three times daily Note: Titrated to 20-200 mg daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia Age: 2-12 years |
Dose: Oral – Initially, 0.5 mg/kg Frequency: daily in divided doses Note: increased gradually until optimum effect obtained. Maximum: 3 mg/kg daily. |
|
Indication: Schizophrenia Age: greater than 12 years |
Dose: Oral – Initial 50-100 mg Frequency: every 8 hours Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Lower initial doses and more gradual dosage increase |
Administration
- Take with food
- Follow prescribed schedule
Side Effect
- Tardive dyskinesia
- leucopenia
- neutropenia
- agranulocytosis
- drowsiness
- pseudoparkinsonism and other extrapyramidal symptoms 60%
- Dry mouth
- blurred vision
- constipation
- nausea
- vomiting
- diarrhoea
- nasal stuffiness
- pallor
- galactorrhoea
- breast engorgement
- amenorrhoea
- inhibition of ejaculation
- peripheral oedema
- dermatitis
- skin eruptions
- Rarely
- nocturnal confusion
- hyperactivity
- lethargy
- psychotic reactions
- restlessness
- headache
- photosensitivity
- parotid swelling
- Prolongation of QTc interval resulting to torsades de pointes type arrhythmias and polymorphic ventricular tachycardia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Anticholinergics
|
Potentiates adverse effects
|
|
TCAs
|
Raised blood levels of both drugs
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Comatose States
|
May worsen consciousness
|
|
Severe CVS Disorders
|
Risk of cardiac complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.