Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Bladder cancer Age: Adult |
Dose: Intravesical – Up to 60 mg instilled in 30-60 mL of sterile water or sodium chloride 0.9% Frequency: once a week Duration: up to 4 weeks Note: Instilled into the bladder of patient previously dehydrated for 8-12 hours and retained for 2 hours. Reposition patient every 15 minutes for maximum area contact. |
|
Indication: Prophylaxis of recurrence after surgical removal of bladder cancer Age: Adult |
Dose: Intravesical – Up to 60 mg Frequency: at intervals of 1-2 weeks Duration: up to 8 instillations |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Class 3 beta-thalassemia before allogeneic hematopoietic stem cell transplantation Age: Pediatric |
Dose: Intravenous – 5 mg/kg Frequency: Two administrations approximately 12 hours apart Duration: on Day -6 before transplantation |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not mentioned Note: Caution; may require lower dose; limit use to cases where benefit outweigh risk |
Administration
- IV administration over 1 minute
- Must be filtered before use
Side Effect
- GI disturbances
- fatigue
- weakness
- headache and dizziness
- hypersensitivity reactions
- blurred vision and conjunctivitis
- amenorrhoea
- impaired fertility
- local irritation
- frank chemical or haemorrhagic cystitis
- depigmentation of periorbital skin (eye drops)
- Bone marrow depression
- mutagenesis
- teratogenesis and carcinogenesis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other Alkylating Agents (Cyclophosphamide, Busulfan, Melphalan), Irradiation
|
Enhance effect
|
|
Succinylcholine, Other neuromuscular-blocking agents
|
Prolongs action
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Myelosuppression
|
Risk of infection and bleeding
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store and transport refrigerated (2°C-8°C). Do not freeze.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.