Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Smoking Cessation Condition: Quit smoking date regimen (Days 1-3) |
Dose: Oral – 0.5 mg Frequency: once daily Note: Initiate regimen 1 week before quit smoking date. Alternatively, the patient can begin varenicline and then quit smoking between days 8 and 35 of treatment. |
|
Indication: Smoking Cessation Condition: Quit smoking date regimen (Days 4-7) |
Dose: Oral – 0.5 mg Frequency: twice daily Note: Initiate regimen 1 week before quit smoking date. Alternatively, the patient can begin varenicline and then quit smoking between days 8 and 35 of treatment. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild-to-moderate renal impairment (creatinine clearance greater than or equal to 30 mL/min) |
Dose: Dose: Note: No dosage adjustment required |
|
Condition: Renal impairment Severe (CrCl < 30 mL/min) |
Dose: Oral - 0.5 mg once daily initially Note: May increase to Oral - 0.5 mg every 12 hours |
Administration
- Take after eating
- Take with full glass of water
Side Effect
- Nausea (15-40%
- dose related)
- Abnormal dreams
- Headache
- Insomnia
- Appetite changes
- Chest pain
- Constipation
- Dry mouth
- Dyspepsia
- Dyspnea
- Flatulence
- Gastroesophageal reflux disease (GERD)
- Fatigue or lethargy
- Pruritus
- Rash
- Somnolence
- Rhinorrhea
- Vomiting
- Upper respiratory tract disorder
- Abnormal liver function tests
- Anemia
- Anxiety
- Arrhythmia
- Arthralgia
- Depression
- Diarrhea
- Dizziness
- Epistaxis
- Hypertension
- Myocardial infarction (MI)
- Polyuria
- Respiratory disorder
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Transdermal nicotine
|
Increased incidence of adverse effects (nausea, vomiting)
|
|
Cimetidine
|
Increased exposure
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Non-smokers
|
Not indicated for non-smokers
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.