Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Fungal infections Age: Adult |
Dose: Oral – 200 mg Frequency: once daily Note: may increase to 400 mg once daily if clinical response is insufficient. Continue treatment until symptoms have cleared and cultures have become negative. |
|
Indication: Chronic vag candidiasis Age: Adult |
Dose: Oral – 400 mg Frequency: once daily Duration: 5 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Fungal infections Age: Child: greater than 2 years |
Dose: Oral – 3.3-6.6 mg/kg/day Frequency: once daily Note: Treatment duration: 1-2 weeks for candidiasis |
|
Indication: Recalcitrant dermatophyte infections Age: Child: greater than 2 years |
Dose: Oral – 3.3-6.6 mg/kg/day Frequency: once daily Duration: at least 4 weeks |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet – Dosage adjustment not needed Note: Renal impairment: No dosage adjustment needed. |
Administration
- Take with food
- Take at regular times
Side Effect
- Nausea and vomiting (3-10%)
- Pruritus (2%)
- Abdominal pain (1%)
- Alopecia
- Headache
- Dizziness
- Hyperlipidemia
- Somnolence
- Fever
- Chills
- Bulging fontanelles
- Depression
- Gynecomastia
- Diarrhea
- Impotence
- Thrombocytopenia
- Leukopenia
- Hemolytic anemia
- Erythema multiforme
- Orthostatic hypotension
- Jaundice
- Dyspepsia
- Dysgeusia
- Hepatotoxicity
- Decreased platelet count
- Xeroderma
- Photophobia
- Hepatotoxicity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antimuscarinics (Atropine, Hyoscine, Ipratropium), antacids, H2-blockers, PPIs (Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, Rabeprazole), sucralfate
|
Reduced absorption
|
|
Rifampicin, isoniazid, other specified drugs**
|
Reduced plasma concentrations
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Preexisting Liver Disease
|
Risk of liver toxicity
|
|
Porphyria
|
Risk of acute attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.