Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is an anti-nausea medication. It works by blocking specific receptors in the brain that reduce feelings of nausea.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Can be taken with or without food • Take as prescribed • Complete full course

Question 3

When should this medicine not be used?

Accepted Answer

• Do not use during pregnancy • Use caution with hormonal contraceptives • Do not use in children under 12 years

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• May reduce effectiveness of hormonal contraceptives • Use additional contraception during treatment and for 2 months after • Not known if excreted in breast milk; use caution when breastfeeding

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Limited data on use during pregnancy • Use only if potential benefit justifies risk to fetus • May reduce efficacy of hormonal contraceptives

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• May reduce effectiveness of hormonal contraceptives • Use additional contraception during treatment and for 2 months after • Not known if excreted in breast milk; use caution when breastfeeding

Question 7

Is this medicine suitable for children and elderly?

Accepted Answer

• No dose adjustment needed for kidney problems or dialysis • No adjustment needed for mild/moderate liver problems • No data for severe liver problems

Question 8

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's time for your next dose, skip the missed dose. • Never take two doses in one day. • For twice-daily dosing: If less than 6 hours until your next dose, skip the missed dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 9

What should be done in case of an overdose?

Accepted Answer

• Symptoms: Drowsiness, headache. • Treatment: Supportive care. • Note: Doses up to 600mg generally well tolerated, not removed by dialysis.

Question 10

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Headache, fatigue, loss of appetite, constipation, diarrhea, hiccups • What to do: Take as prescribed with chemotherapy; Report severe reactions; Stay hydrated; Complete full course; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 11

What medical indications are treated with Aprepitant?

Accepted Answer

Aprepitant (Anti-Emetic Drugs) is a pharmaceutical active substance. It is indicated for the treatment of Nausea & Vomiting After Surgery, Nausea & Vomiting Caused By Chemotherapy.

Question 12

What is the recommended dosage for Aprepitant?

Accepted Answer

Standard adult dosage: orally – 125 mg (once). Pediatric dosage: Oral suspension – Safety and efficacy not established. Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 13

Is Aprepitant safe during pregnancy and breastfeeding?

Accepted Answer

Aprepitant is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 14

What are the common side effects of Aprepitant?

Accepted Answer

**More than 10% (only seen in CINV)**; Headache;Asthenia/fatigue;Anorexia;Constipation;Diarrhea;Nausea;Alopecia;Hiccups; **1-10% (selected)**; Dizziness;Insomnia;Bradycardia;Hypotension;Pharyngolargeal pain;Mucosal infla

Clinical Information	Administration Information
Indication: Prevention of Chemotherapy Induced Nausea and Vomiting Age: Adult	Dose: orally – 125 mg Frequency: once Duration: 1 hour prior to chemotherapy treatment (Day 1) Note: Given for 3 days as part of the chemotherapy-induced nausea and vomiting (CINV) regimen that includes a corticosteroid and a 5-HT3 antagonist.
Indication: Prevention of Chemotherapy Induced Nausea and Vomiting Age: Adult	Dose: orally – 80 mg Frequency: once daily in the morning Duration: Days 2 and 3 Note: Given for 3 days as part of the chemotherapy-induced nausea and vomiting (CINV) regimen that includes a corticosteroid and a 5-HT3 antagonist.

Clinical Information	Administration Information
Indication: Chemotherapy-Induced Nausea and Vomiting Age: less than 6 months Condition: Oral suspension	Dose: Oral suspension – Safety and efficacy not established
Indication: Chemotherapy-Induced Nausea and Vomiting Age: less than 12 years Condition: Capsule	Dose: Capsule – Safety and efficacy not established

Clinical Information	Administration Information
Condition: Renal impairment Severe (Creatinine Clearance less than 30 mL/min)	Dose: Oral – Not specified Note: Decreased Area Under the Curve of total aprepitant (unbound and protein bound) by 21% and peak plasma concentration decreased by 32%, compared to healthy subjects (Creatinine Clearance greater than 80 mL/min)
Condition: End-stage renal disease undergoing hemodialysis	Dose: Oral – Not specified Note: Decreased Area Under the Curve of total aprepitant by 42% and peak plasma concentration decreased by 32%

Drug Name	Risk Factors
CYP3A4 inducers	May reduce efficacy of Aprepitant
Phenytoin, Tolbutamide, Warfarin	May decrease concentrations

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

Is this medicine suitable for children and elderly?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources