Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Allergic conditions Symptomatic relief of allergy, such as hay fever, urticaria (Pruritus) Age: Adult |
Dose: Oral – 4 mg Frequency: three times daily Note: Adjusted as necessary. Usual: 12-16 mg daily in 3-4 divided doses. Maximum: 32 mg/day. |
|
Indication: Treatment and prophylaxis of migraine and other vascular headaches (Off-label) Age: Adult |
Dose: Oral – 4 mg Note: May be repeated after 30 minutes. Not to exceed 8 mg within a 4- to 6-hour period. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Allergic conditions Age: Child: 2-6 years |
Dose: Oral – 2 mg Frequency: twice daily or three times daily Note: Maximum: 12 mg daily |
|
Indication: Allergic conditions Age: Child: 7-14 years |
Dose: Oral – 4 mg Frequency: twice daily or three times daily Note: Maximum: 16 mg daily |
Administration
- Can be taken with or without food
- Take with meals to reduce stomach upset
Side Effect
- Psychiatric/neurologic CNS depression
- drowsiness
- sedation ranging from mild drowsiness to deep sleep (most frequent)
- dizziness
- lassitude
- disturbed coordination
- less commonly
- restlessness
- insomnia
- tremors
- euphoria
- nervousness
- irritability
- delirium
- seizures
- toxic psychosis
- paresthesia
- Muscular Weakness
- Cardiovascular Palpitation
- tachycardia
- palpitation
- ECG changes (eg widened QRS)
- arrhythmias (eg extrasystole, heart block)
- hypotension
- hypertension
- dizziness
- sedation
- hypotension
- GI Epigastric distress
- anorexia
- nausea
- vomiting
- diarrhea
- constipation
- Hepatic Cholestasis
- hepatitis
- hepatic failure
- hepatic function abnormality
- jaundice (rare)
- Skin Eczema
- pruritus
- inflammation
- papular rash
- erythema on exposed skin
- Sensory Visual disturbances
- blurred vision
- diplopia
- tinnitus
- acute labyrinthitis
- Renal Dysuria
- urinary retention
- Respiratory Thickening of bronchial secretions
- wheezing
- nasal stuffiness
- Other Vertigo
- sweating
- chills
- early menses
- headache
- impotence
- dryness of mouth
- nose
- and throat
- facial dyskinesia
- tightness of chest
- faintness
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CNS depressants
|
May have additive effects
|
|
MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide)
|
Potentially Fatal: Prolong and intensify the anticholinergic effects of antihistamines
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Narrow-Angle Glaucoma
|
Risk of increased eye pressure
|
|
Acute Asthma Attack
|
May worsen breathing problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.