Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Streptococcal Infections Group A (upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas) Age: Adult |
Dose: Intramuscular Injection – 2,400,000 units Frequency: Single session Note: Usually given using multiple intramuscular sites when indicated. Alternative schedule: one-half (1/2) total dose on day 1 and one-half (1/2) on day 3. |
|
Indication: Pneumococcal Infections (except pneumococcal meningitis) Age: Adult |
Dose: Intramuscular Injection – 1,200,000 units Frequency: Repeated every 2 or 3 days Duration: Until temperature is normal for 48 hours Note: Other forms of penicillin may be necessary for severe cases. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Streptococcal Infections Group A (upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas) Age: Pediatric |
Dose: Intramuscular Injection – 2,400,000 units Note: Treatment with the recommended dosage is usually given at a single session using multiple intramuscular sites when indicated. An alternative dosage schedule may be used, giving one-half (1/2) the total dose on day 1 and one-half (1/2) on day 3. |
|
Indication: Streptococcal Infections Group A (upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas) Age: Pediatric |
Dose: Intramuscular Injection – 900,000 units to 1,200,000 units Note: Treatment with the recommended dosage is usually given at a single session using multiple intramuscular sites when indicated. An alternative dosage schedule may be used, giving one-half (1/2) the total dose on day 1 and one-half (1/2) on day 3. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment with Creatinine Clearance 10-50 mL/minute |
Dose: Dosage – Decrease dose by 25% Note: Renal dose adjustment |
|
Condition: Renal Impairment with Creatinine Clearance less than 10 mL/minute |
Dose: Dosage – Decrease dose by 50-70% Note: Renal dose adjustment |
Administration
- Medical professional use
- Deep muscle injection
Side Effect
- As with other penicillins
- untoward reactions of the sensitivity phenomena are likely to occur
- particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy
- asthma
- hay fever
- or urticaria
- the following skin eruptions (maculopapular to exfoliative dermatitis)
- urticaria
- laryngeal edema
- fever
- eosinophilia
- other serum sickness-like reactions (including chills, fever, edema, arthralgia and prostration)
- anaphylaxis including shock and death
- Gastrointestinal Pseudomembranous colitis
- Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid
|
Increases and prolongs serum penicillin levels
|
|
Tetracycline
|
May antagonize bactericidal effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at room temperature.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.