Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Smoking cessation Age: Adult Condition: Modified-release preparation |
Dose: Oral - 150 mg Frequency: initially once daily for 6 days, then twice daily Duration: 7–9 weeks Note: Maximum per dose 150 mg, minimum 8 hours between doses; start treatment 1–2 weeks before target stop date; discontinue if abstinence not achieved at 7 weeks; consider maximum 150 mg daily in patients with risk factors for seizures; maximum 300 mg per day. |
|
Indication: Depression Age: Adult |
Dose: Oral - 100 mg Frequency: twice daily Note: Starting dose 200 mg per day; increase dose gradually to reduce seizure risk. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Form – Not specified Note: Use caution; consider dose reduction |
Administration
- Swallow whole
- Don't crush or chew
Side Effect
- Headache (25-34%)
- Dry mouth (17-28%)
- Nausea (1-18%)
- Weight loss (15-20%)
- Insomnia (11-20%)
- Agitation (2-32%)
- Dizziness (6-22%)
- Pharyngitis (3-13%)
- Constipation (5-10%)
- Infection (8-9%)
- Abdominal pain (2-9%)
- Anxiety (5-7%)
- Diarrhea (5-7%)
- Tinnitus (3-6%)
- Tremor (3-6%)
- Nervousness (3-5%)
- Anorexia (3-5%)
- Palpitation (2-6%)
- Myalgia (2-6%)
- Sweating (2-5%)
- Rash (1-5%)
- Sinusitis (1-5%)
- Weight gain (4%)
- Chest pain (3-4%)
- Urinary frequency (2%)
- Vaginal hemorrhage (2%)
- Pruritus (2-4%)
- Vomiting (2-4%)
- Arthralgia (1-4%)
- Flushing (1-4%)
- Migraine (1-4%)
- Decreased memory (Less than 3%)
- Irritability (2-3%)
- Somnolence (2-3%)
- Dysphagia (Less than 2%)
- Arthritis (2%)
- Paresthesia (1-2%)
- Fever (1-2%)
- Twitch (1-2%)
- Seizures (0.4% [Less than 450 mg/day]
- More than 3% [More than 450 mg/day]
- may be increased risk with concomitant ECT)
- Confusion
- Cystitis
- Erythema
- Ataxia
- Coma
- EEG abnormality
- Euphoria
- Gastric reflux
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Neuroleptics, Lithium, TCAs, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam), Alcohol
|
May lower seizure threshold
|
|
Neuroleptics, lithium, tricyclic Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam)
|
Increased risk of side effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Seizure Disorder
|
Risk of increased seizures
|
|
Bulimia/Anorexia
|
Risk of seizures
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.