Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Partial-Onset Seizures Condition: Monotherapy or adjunctive therapy |
Dose: by mouth – Initial 400 mg Frequency: once daily Note: For some patients, treatment may be initiated at 800 mg once daily if the need for additional seizure reduction outweighs an increased risk of adverse reactions during initiation. |
|
Indication: Partial-Onset Seizures Condition: Titration |
Dose: by mouth – Increase dose by weekly increments of 400-600 mg Note: Based on clinical response and tolerability. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Dosage Form – Not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Moderate-to-severe (Creatinine Clearance less than 50 mL/minute) |
Dose: Not specified – Reduce initial, titration, and maintenance doses by 50% Note: May adjust titration and maintenance doses according to clinical response |
Administration
- Can take with or without food
- Take at regular times
Side Effect
- Dizziness (20-28%)
- Somnolence (11-18%)
- Nausea (10-16%)
- Headache (13-15%)
- Diplopia (9-11%)
- Vomiting (6-10%)
- Fatigue (4-7%)
- Blurred vision (5-6%)
- Ataxia (4-6%)
- Vertigo (2-6%)
- Diarrhea (2-4%)
- Tremor (2-4%)
- Balance disorder (3%)
- Asthenia (2-3%)
- Falls (1-3%)
- Depression (1-3%)
- Rash (1-3%)
- Constipation (2%)
- Abdominal pain (2%)
- Gait disturbance (2%)
- UTI (2%)
- Hyponatremia (2%)
- Insomnia (2%)
- Visual impairment (1-2%)
- Gastritis (1-2%)
- Peripheral edema (1-2%)
- Dysarthria (1-2%)
- Memory impairment (1-2%)
- Nystagmus (1-2%)
- Cough (1-2%)
- Hypertension (1-2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Drug Hypersensitivity
|
Risk of allergic reaction
|
|
Carboxamide Allergy
|
Risk of cross-sensitivity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light and moisture. Keep the medicine out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.