Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Snake envenomation Condition: Initial dose |
Dose: Antiserum Injection – 5-10 vials Frequency: slow intravenous infusion Note: Administer either undiluted at a speed of not more than 2 ml/minute or after dilution with normal /glucose saline at a rate of 5-10 ml/kg body weight over 1 hour. Constant monitoring of the vital signs at frequent intervals during initial 1 hour is recommended. |
|
Indication: Haemotoxic snake bite Condition: Confirmation of blood still incoagulable after 6 hours of initial dose |
Dose: Antiserum Injection – 5-10 vials Frequency: slow intravenous route Note: Requirement of further dosing depends on extent of reversal of coagulopathy confirmed after 6 hours of antiserum administration by 20 minute whole blood clotting test. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Snake envenomation Age: Pediatric |
Dose: Antivenom Injection – 5-10 vials Frequency: initial dose Note: Children should receive the same dose as adults. Administer by slow intravenous infusion either undiluted at a speed of not more than 2 ml/minute or after dilution with normal /glucose saline at a rate of 5-10 ml/kg body weight over 1 hour. Constant monitoring of vital signs at frequent intervals during initial 1 hour is recommended. |
|
Indication: Snake envenomation Age: Pediatric Condition: Incoagulable blood or no signs of reversal of paralysis after 6 hours for haemotoxic or 1 hour for neurotoxic bite |
Dose: Antivenom Injection – 5-10 vials Frequency: further dose Note: Administer by slow intravenous route only. Requirement depends on extent of reversal of coagulopathy confirmed after 6 hours of antiserum administration by Whole Blood Clotting Test in haemotoxic bite or if symptoms persist or worsen or in respiratory failure in neurotoxic bite after 1 hour. |
Administration
- Give IV only
- Give slowly or diluted
Side Effect
- urticaria
- itching
- fever
- chills or rigor
- nausea
- vomiting
- diarrhoea
- abdominal cramps
- tachycardia
- hypotension
- bronchospasm
- and angioedema
- fever
- urticaria
- edema
- nausea and vomiting
- Occasionally neurological manifestations develop
- Pain and muscle weakness are frequently present
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Sulfonylureas, insulin
|
Increased risk of hypoglycaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Equine Antisera Allergy
|
Risk of severe allergic reaction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Lyophilized Snake venom antiserum is stable at room temperature and does not require special storage facilities. Ideally, it should be stored in a cool & dark place and do not expose to excessive heat.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.