Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Myelodysplastic disease Age: Adult |
Dose: Oral – 10 mg Frequency: once daily Duration: for 21 consecutive days of repeated 28-day cycle |
|
Indication: Multiple myeloma Age: Adult Condition: In combination with dexamethasone |
Dose: Oral – Lenalidomide: 25 mg Frequency: once daily Duration: for 21 consecutive days of repeated 28-day cycle |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Myelodysplastic disease Condition: Moderate renal impairment |
Dose: Tablet – 5 mg Frequency: once daily |
|
Indication: Myelodysplastic disease Condition: Severe renal impairment (not requiring dialysis) |
Dose: Tablet – 5 mg Frequency: every other day |
Administration
- Take at the same time every day
- Swallow whole with water
Side Effect
- Thrombocytopenia (62%)
- Neutropenia (59%)
- Diarrhea (48%)
- Pruritus (42%)
- Nausea (35%)
- Rash (35%)
- Fatigue (31%)
- Constipation (24%)
- Arthralgia (22%)
- Back pain (21%)
- Peripheral edema (21%)
- Pyrexia (21%)
- Dizziness (20%)
- Headache (20%)
- Cough (19%)
- Muscle cramp (18%)
- Dyspnea (17%)
- URTI (15%)
- Anemia (12%)
- Pneumonia (12%)
- UTI (11%)
- (critical AEs)
- Tumor flare reaction - MCL (10%)
- Abdominal pain (8%)
- Leukopenia (8%)
- Myalgia (8%)
- Pain (7%)
- Bronchitis (6%)
- Rhinitis (6%)
- Febrile neutropenia (5%)
- Peripheral neuropathy (5%)
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- erythema multiforme
- angioedema
- Acute hepatic failure
- toxic
- cytolytic
- cholestatic and mixed cytolytic/ cholestatic hepatitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Erythropoietic agents
|
May increase risk of thrombosis
|
|
Digoxin, ketoconazole, itraconazole, ciclosporin, verapamil, quinidine, clarithromycin
|
May increase plasma concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Women of Childbearing Age Without Contraception
|
Risk of birth defects
|
|
Drug Hypersensitivity
|
Risk of severe reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C in a dry place. Protect from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.