Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Tablet – Glimepiride 1 mg or 2 mg and Metformin sustained release 500 mg Frequency: once daily Note: Initial recommended dose is one tablet once daily. The maximum recommended dose for glimepiride is 8 mg daily. The maximum recommended daily dose for metformin sustained-release is 2000 mg in adults. Dosage should be individualized on the basis of both effectiveness and tolerance. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Take with breakfast or first main meal
- Take at same time each day
Side Effect
- Diarrhoea
- vomiting
- metallic taste
- rash
- isolated transaminase elevations
- cholestatic jaundice
- allergic skin reactions
- photosensitivity reactions
- leukopaenia
- agranulocytosis
- thrombocytopaenia
- haemolytic anaemia
- aplastic anaemia
- pancytopaenia
- blurred vision
- Lactic acidosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cationic drugs (e.g. amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, vancomycin)
|
May increase risk of lactic acidosis
|
|
Miconazole, phenylbutazone
|
Increases hypoglycemic effect of glimepiride
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Renal Disease
|
Risk of lactic acidosis
|
|
Diabetic Ketoacidosis
|
Requires insulin treatment
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool (not exceeding 25°C) and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.