| Clinical Information | Administration Information |
|---|---|
|
Indication: Hormone receptor positive, HER2-negative locally advanced carcinoma of breast or Hormone receptor positive, HER2-negative metastatic carcinoma of breast Age: Adult |
Dose: Oral – 125 mg Frequency: once daily Duration: for 21 days, followed by 7 days off, repeat every 28 days until disease progression or unacceptable toxicity Note: In combination with aromatase inhibitor, or in combination with fulvestrant in women who have received prior endocrine therapy. |
|
Indication: Hormone receptor positive, HER2-negative locally advanced carcinoma of breast or Hormone receptor positive, HER2-negative metastatic carcinoma of breast Age: Adult Condition: Recommended first dose reduction |
Dose: Oral – 100 mg Frequency: once daily Note: Dosage modifications may be required according to individual safety or tolerability. |
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: Not recommended for children |
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Mild, moderate, or severe (Creatinine Clearance greater than 15 mL/minute) |
Dose: Not specified – No dose adjustment required Note: No dose adjustment required |
|
Condition: Hemodialysis |
Dose: Not specified – Not studied Note: Not studied |
| Drug Name | Risk Factors |
|---|---|
|
Strong CYP3A inhibitors
|
Increased plasma concentration and systemic exposure
|
|
Moderate CYP3A inducers, strong CYP3A inducers
|
Decreased plasma concentration
|
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.