Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult |
Dose: Oral tablet – 2.5 mg/6.25 mg Frequency: once daily Note: Initial dose. Increase based on clinical response in 2 weeks. Maximum: bisoprolol 20 mg/hydrochlorothiazide 12.5 mg once daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Take with or without food
- Take in morning
Side Effect
- Arthralgia (3%)
- asthenia (2%)
- cough (3%)
- diarrhea (4%)
- dizziness (10%)
- dry mouth (1%)
- dyspnea (2%)
- fatigue (8%)
- headache (11%)
- hypoaesthesia (2%)
- insomnia (3%)
- nausea (2%)
- peripheral edema (4%)
- pharyngitis (2%)
- rhinitis (4%)
- sinusitis (2%)
- upper respiratory infection (5%)
- vomiting (2% )
- Anorexia
- Epigastric distress
- Hypokalemia
- Hypotension
- Orthostatic hypotension
- Phototoxicity
- Aggravate CHF
- cold extremeties
- decrease HDL
- depression
- hypotension
- increase bronchospasm
- increase triglycerides
- mask symptoms of hypoglycemia
- Agranulocytosis
- anaphylaxis
- anemia
- Confusion
- erythema multiforme skin reactions including Stevens-Johnson syndrome
- Exfoliative dermatitis including toxic epidermal necrolysis
- Hypomagnesemia
- hyponatremia
- hypochloremia
- dizziness
- fatigue
- headache
- hypercalcemia
- hyperuricemia
- hyperglycemia
- hyperlipidemia
- hypercholesterolemia
- muscle weakness or cramps
- nausea
- purpura
- rash
- vertigo
- vomiting
- AV block
- bradycardia
- Rare but may occur in patients with preexisting cardiac disease
- Includes severe bronchospasm
- hypoglycaemia
- hypotension
- orthostatic hypotension
- bradyarrhythmias
- 'Rebound phenomenon' leading to unstable angina or MI on sudden withdrawal
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Class I antiarrhythmic drugs
|
May potentiate AV conduction time
|
|
Catecholamine-depleting Drugs (specific agents that deplete catecholamines)
|
May produce excessive sympathetic activity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Low Cardiac Output, Cardiac Failure
|
Can worsen heart function
|
|
Bradycardia, Heart Block
|
Can worsen heart rhythm
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.