Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Diarrhea-predominant irritable bowel syndrome (IBS-D) Age: Adult |
Dose: Tablet – 100 mg Frequency: twice daily Note: Take with food; discontinue in patients who develop severe constipation lasting greater than 4 days |
|
Indication: Diarrhea-predominant irritable bowel syndrome (IBS-D) Age: Adult Condition: Mild-to-moderate hepatic impairment (Child-Pugh A or B) |
Dose: Tablet – 75 mg Frequency: twice daily Note: Monitor for impaired mental or physical abilities needed to perform potentially hazardous activities |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Dosage – Not available Note: No approved pediatric dosage available |
Administration
- Take with food
- Take at regular intervals
Side Effect
- Constipation (7-8%)
- Nausea (7-8%)
- Abdominal pain (6-7%)
- URT infection (3-5%)
- Vomiting (4%)
- Nasopharyngitis (3-4%)
- Abdominal distention (3%)
- Bronchitis (3%)
- Dizziness (3%)
- Flatulence (3%)
- Rash (3%)
- Increased ALT (2-3%)
- Fatigue (2-3%)
- Viral gastroenteritis (1-3%)
- Gastrointestinal GERD
- Feeling drunk
- AST
- Sedation
- somnolence
- Euphoric mood
- Respiratory Asthma
- bronchospasm
- respiratory failure
- wheezing
- Severe constipation
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No gallbladder
|
Risk of sphincter of Oddi spasm
|
|
Gallbladder/biliary duct obstruction
|
Can worsen biliary complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place, protect from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.