Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is an antibiotic combination. It's used to treat complicated bacterial infections. It works by inhibiting bacterial cell wall formation and destroying antibiotic-resistant enzymes.

Question 2

When and how should this medicine be taken?

Accepted Answer

• First step: - Mix with 10mL sterile water/saline - Gently mix until clear • Second step: - Dilute to 50-250mL total - Solution should be clear/light yellow • Use within: - 12 hours at room temperature - 24 hours if refrigerated • Give through IV over 2 hours

Question 3

When should this medicine not be used?

Accepted Answer

• In severe allergies • In brain disease • During pregnancy

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• May cause allergic reactions • Watch for diarrhea • Use caution in kidney problems • May cause nervous system issues

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Use only if potential benefit outweighs potential risk • Limited data available on use during pregnancy • Consult doctor before use

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• May cause allergic reactions • Watch for diarrhea • Use caution in kidney problems • May cause nervous system issues

Question 7

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For thrice-daily dosing: If there's more than 3 hours until your next dose, take the missed dose. • Take your next dose at the regular time. • If you're unsure, contact your doctor or pharmacist.

Question 8

What should be done in case of an overdose?

Accepted Answer

• Symptoms: Vomiting, headache, neurological symptoms. • Treatment: Discontinue drug, consider hemodialysis, supportive care.

Question 9

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Diarrhea, nausea, vomiting, headache, anxiety, liver enzyme changes • What to do: Complete full course, report severe diarrhea, maintain hydration; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 10

What medical indications are treated with Ceftazidime + Avibactam?

Accepted Answer

Ceftazidime + Avibactam (Third Generation Cephalosporins) is a pharmaceutical active substance. It is indicated for the treatment of Hospital-Acquired Bacterial Pneumonia, Intra-Abdominal Infections, Urinary Tract Infection (UTI), Ventilator associated Bacterial Pneumonia.

Question 11

What is the recommended dosage for Ceftazidime + Avibactam?

Accepted Answer

Standard adult dosage: Intravenous – 2.5 g (2 g/0.5 g) (every 8 hours). Pediatric dosage: Intravenous – 50 mg/kg (ceftazidime 40 mg/kg and avibactam 10 mg/kg) (every 8 hours). Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 12

Is Ceftazidime + Avibactam safe during pregnancy and breastfeeding?

Accepted Answer

Ceftazidime + Avibactam is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 13

What are the common side effects of Ceftazidime + Avibactam?

Accepted Answer

**1-10% (in cIAI plus metronidazole)**; Diarrhea (8%);Nausea (7%);Vomiting (5%);Headache (3%);Dizziness (2%);Abdominal pain (1%); **1-10% (in cUTI)**; Diarrhea (3%);Nausea (3%);Constipation (2%);Upper abdominal pain (1%)

Clinical Information	Administration Information
Indication: Complicated intra-abdominal infections Condition: In combination with metronidazole	Dose: Intravenous – 2.5 g (2 g/0.5 g) Frequency: every 8 hours Duration: 5-14 days Note: Infused over 2 hours. Caused by susceptible gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Klebsiella oxytoca, Citrobacter freundii complex, and Pseudomonas aeruginosa.
Indication: Complicated urinary tract infections Condition: Including pyelonephritis	Dose: Intravenous – 2.5 g (2 g/0.5 g) Frequency: every 8 hours Duration: 7-14 days Note: Infused over 2 hours. Caused by susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter aerogenes, Enterobacter cloacae, Citrobacter freundii, Proteus mirabilis, and Pseudomonas aeruginosa.

Clinical Information	Administration Information
Age: Adult Condition: Renal impairment with Creatinine Clearance greater than 50 mL/min	Dose: Intravenous – No dose adjustment required Note: Standard dosing applies
Age: Adult Condition: Renal impairment with Creatinine Clearance 31-50 mL/min	Dose: Intravenous – 1.25 grams (1 gram/0.25 grams) Frequency: every 8 hours

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources