Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Locally advanced or metastatic non-small cell lung carcinoma Age: Adult |
Dose: Oral – 250 mg Frequency: once daily Note: Until disease progression or unacceptable toxicity |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Can be taken with or without food
- May be dispersed in water if needed
Side Effect
- Skin reactions
- all grades (47%)
- Diarrhea
- all grades (29%)
- Decreased appetite
- all grades (17%)
- Vomiting
- all grades (14%)
- Increased ALT
- all grades (11.4%)
- Increased AST
- all grades (7.9%)
- Stomatitis
- all grades (7%)
- Conjunctivitis
- blepharitis
- and dry eye (6.7%)
- Conjunctivitis/blepharitis/dry eye (6%)
- Increased ALT
- grades 3-4 (5.1%)
- Nail disorders
- all grades (5%)
- Diarrhea
- grades 3-4 (3%)
- Increased AST
- grades 3-4 (3%)
- Increased bilirubin
- all grades (2.7%)
- Decreased appetite
- grades 2-3 (2.3%)
- Skin reactions
- grades 3-4 (2%)
- Interstitial lung disease
- all grades (1.3%)
- Vomiting
- grades 3-4 (1.2%)
- Interstitial lung disease
- grades 3-4 (0.7%)
- Increased bilirubin
- grades 3-4 (0.7%)
- Stomatitis
- all grades (0.3%)
- Corneal erosion and aberrant eyelash growth (0.2%)
- Nail disorders
- grades 3-4 (0.1%)
- Gastrointestinal perforation (0.1%)
- Ocular keratitis (0.1%)
- Erythema multiforme and dermatitis bullous (0.08%)
- Fatal hepatoxicity (0.04%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine, barbiturates)
|
May reduce serum gefitinib levels
|
|
Potent CYP3A4 inhibitors (e.g. itraconazole, ketoconazole)
|
Plasma concentrations may be increased
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.