Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer Age: Adults Condition: Complete or partial response to platinum-based chemotherapy |
Dose: Tablet – 300 mg Frequency: once daily Duration: continue until disease progression or unacceptable toxicity Note: Indicated for maintenance treatment |
|
Indication: Recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer Age: Adults Condition: Mild hepatic impairment |
Dose: Tablet – 300 mg Frequency: once daily Note: No dose adjustment required |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (Mild-to-moderate, Creatinine Clearance greater than or equal to 30 mL/min) |
Dose: Not specified Note: No dose adjustment required |
|
Condition: Renal impairment (Severe or End-Stage Renal Disease) |
Dose: Not specified Note: Not studied |
Administration
- Take with or without food
- Take at bedtime
Side Effect
- Nausea (74%)
- Thrombocytopenia (61%)
- Fatigue/asthenia (57%)
- Anemia (50%)
- Constipation (40%)
- Vomiting (34%)
- Abdominal pain/distention (33%)
- Neutropenia (30%)
- Thrombocytopenia, grades 3 or 4 (29%)
- Insomnia (27%)
- Headache (26%)
- Anemia, grades 3 or 4 (25%)
- Nasopharyngitis (23%)
- Rash (21%)
- Hypertension (20%)
- Neutropenia, grades 3 or 4 (20%)
- Mucositis/stomatitis (20%)
- Diarrhea (20%)
- Dyspepsia (20%)
- Myalgia (19%)
- Back pain (18%)
- Dyspepsia (18%)
- Dizziness (18%)
- Leukopenia (17%)
- Cough (16%)
- UTI (13%)
- Arthralgia (13%)
- Anxiety (11%)
- Palpitations (10%)
- Dry mouth (10%)
- AST/ALT elevation (10%)
- Dysgeusia (10%)
- Hypertension, grade 3 or 4 (9%)
- Leukopenia, grades 3 or 4 (5%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Do not store above 30°C. Do not take Niraparib if it is suspected of having been exposed to temperatures greater than 40°C or 104°F. Keep Niraparib out of the reach and sight of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.