Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Venous Thromboembolism Prevention Age: Adults Condition: Hospitalized for acute medical illness at risk for thromboembolic complications owing to moderate or severe restricted mobility and other risk factors for venous thromboembolism |
Dose: by mouth – 160 mg Frequency: Initial single dose |
|
Indication: Venous Thromboembolism Prevention Age: Adults Condition: Hospitalized for acute medical illness at risk for thromboembolic complications owing to moderate or severe restricted mobility and other risk factors for venous thromboembolism |
Dose: by mouth – 80 mg Frequency: once daily Duration: 35-42 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Dose: Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Mild-to-moderate (Creatinine Clearance greater than 30 mL/min) |
Dose: Not specified – No dose adjustment is needed Note: No dose adjustment is needed |
|
Condition: Renal impairment Severe (Creatinine Clearance greater than 15 to less than 30 mL/min) |
Dose: by mouth (oral) – Initial single dose of 80 mg, then 40 mg Frequency: once daily Duration: 35-42 days |
Administration
- Take with food
- Take at same time daily
Side Effect
- Clinically relevant nonmajor bleeding (2.45%)
- Epistaxis (2%)
- Hematuria (2%)
- Bleeding
- Major bleeding (0.67%)
- GI bleeding (0.51%)
- Intracranial hemorrhage (0.05%)
- Fatal bleeding (0.03%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aspirin, other antiplatelet agents, other Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), heparin, thrombolytic agents, SSRIs, SNRIs, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
Increased bleeding risk
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Pathological Bleeding
|
Risk of severe bleeding complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Protect from light and moisture, store below 30°C. Keep the medicine out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.