Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Endometriosis Age: Adult Condition: Mild hepatic impairment (Child-Pugh A) |
Dose: 150 mg Frequency: once daily Duration: up to 24 months Note: No dosage adjustment required |
|
Indication: Endometriosis Age: Adult Condition: Moderate hepatic impairment (Child-Pugh B) |
Dose: 150 mg Frequency: once daily Duration: limited to 6 months Note: Only the 150-mg once daily regimen is recommended |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not mentioned Note: No dosage adjustment required with any degree of renal impairment or end-stage renal disease (including dialysis) |
Administration
- Take once daily
- With or without food
Side Effect
- Hot flush or night sweats (24-36%)
- Headache (17-20%)
- Nausea (11-16%)
- Insomnia (6-9%)
- Mood altered
- mood swings (5-6%)
- Amenorrhea (4-7%)
- Depressed mood
- depression
- depressive symptoms and/or tearfulness (3-6%)
- Hypersensitivity reactions (5.8%)
- Anxiety (3-5%)
- Arthralgia (3-5%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cyclosporine, gemfibrozil
|
Contraindicated
|
|
Digoxin, ethinylestradiol
|
Increases exposure
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Known Osteoporosis
|
Risk of bone loss
|
|
Severe Hepatic Impairment
|
Risk of drug toxicity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.