Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Local Anesthesia Condition: Local infiltration |
Dose: Injection – 0.25% Note: May increase up to 175 mg (70 mL) |
|
Indication: Regional Anesthesia Condition: Sympathetic block |
Dose: Injection – 0.25% Frequency: 50-125 mg (20-50 mL) |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Local Anesthesia Age: <12 years |
Dose: Injection Note: Not recommended. |
|
Indication: Local Anesthesia Age: infants <6 months Condition: if necessary |
Dose: Injection – decreased dose by 30% Note: Not recommended. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (All severities) |
Dose: Use with caution Note: Pharmacokinetics not evaluated; substantially excreted by the kidneys; may increase bupivacaine exposure and risk of systemic toxicities; consider frequent monitoring for adverse reactions |
Administration
- For medical professional use only
- Must be administered by healthcare provider
Side Effect
- depression
- Hypotension
- bradycardia
- arrhythmias and cardiac arrest
- methaemoglobinaemia
- seizures
- restlessness
- dizziness
- Hypersensitivity
- Prolonged block
- Edema
- Headache
- Hypotension
- Hypoventilation
- Nausea
- Nervousness
- Palpitation
- Respiratory arrest
- Tachycardia
- Tinnitus
- Tremors
- Vomiting
- Cardiac and sudden respiratory arrest
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Hyaluronidase (Enzyme preparations)
|
Enhanced adverse effects
|
|
Cimetidine, Ranitidine
|
Decreased clearance resulting in increased plasma concentrations
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
IV Regional Anaesthesia
|
Risk of systemic toxicity
|
|
Paracervical Block in Obstetrics
|
Risk to fetus
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a cool & dry place, protected from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.