Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Vascular Headache Age: Adult |
Dose: Tablet – 1 tablet (ergotamine tartrate 2 mg and caffeine hydrate 100 mg) Frequency: Initially 1 tablet, then additional doses of 1/2-1 tablet may be taken at half-hourly intervals as needed Note: To be taken as soon as possible at the 1st warning of a migraine attack. Maximum 3 tablets in 24 hours, 4 tablets per attack, 6 tablets per week, and 2 courses of treatment per month. Ensure an interval of at least 4 days between successive treatment courses. |
|
Indication: Vascular Headache Age: Adult Condition: Rectal |
Dose: Suppository – 1 suppository (2 mg ergotamine and 100 mg caffeine) Frequency: 1 suppository at the first sign of a migraine attack; if not relieved, a 2nd dose may be taken no sooner than 1 hour after the first dose Note: Should not be used on a daily basis. Maximum 2 suppositories for any single migraine attack and maximum 5 suppositories during any 7-day period. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Contraindicated Note: Contraindicated |
Administration
- Can be taken with or without food
- Take at first sign of migraine
Side Effect
- Increased BP
- hypotension
- rapid and weak pulse
- palpitations
- arrhythmias
- precordial pain
- coronary infarction
- fibrotic thickening of the heart valves
- Cerebral ischaemia and thrombosis
- blurred vision
- sleep disturbances
- urinary retention
- muscle cramps and joint pains
- GI symptoms such as nausea, vomiting, constipation, abdominal pain
- Dysaesthesia
- paraesthesia
- formication
- tremor
- convulsions
- headache
- extrapyramidal effects
- Anxiety
- depression
- confusion
- hallucinations
- psychomotor impairment
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Alcohol
|
Increased sedative effect
|
|
Lithium
|
Caffeine may increase clearance
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Potent CYP3A4 Inhibitors, Protease Inhibitors
|
Risk of drug interactions
|
|
Hyperthyroidism, Renal/Hepatic Impairment
|
Can worsen organ function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.