Indication: Bowel Preparation

Age: Adults

Condition: Split dose (Preferred dosing method)

Dose: Ready-to-drink solution – 160 mL (1 bottle)

Frequency: Two doses

Note: First dose: Take during the evening before the colonoscopy (eg, 5:00 to 9:00 PM) followed by five 8-ounce drinks of clear liquids before bed; consume clear liquids within 5 hours. Second dose: Take the next day approximately 5 hours before the colonoscopy followed by at least three 8-ounce drinks of clear liquids before the colonoscopy; consume clear liquids within 5 hours up until 2 hours before the time of the colonoscopy.

Indication: Bowel Preparation

Age: Adults

Condition: Day before dose (Alternate method)

Dose: Ready-to-drink solution – 160 mL (1 bottle)

Frequency: Two doses

Note: First dose: Take in the afternoon or early evening (eg, 4:00 to 6:00 PM) before the colonoscopy followed by five 8-ounce drinks of clear liquids before the next dose; consume clear liquids within 5 hours. Second dose: Take approximately 6 hours later in the late evening (eg, 10:00 PM to 12:00 AM), the night before the colonoscopy followed by three 8-ounce drinks of clear liquids before bed; consume clear liquids within 5 hours.

Indication: Bowel Preparation

Age: less than 9 years

Dose: Ready-to-drink solution – Safety and efficacy not established

Note: Safety and efficacy not established

Indication: Bowel Preparation

Age: greater than 9 years

Condition: Split dose regimen

Dose: Ready-to-drink solution – 160 mL (1 bottle)

Frequency: Two doses

Note: First dose: Take during the evening before the colonoscopy (eg, 5:00 to 9:00 PM) followed by five 8-ounce drinks of clear liquids before bed; consume clear liquids within 5 hours. Second dose: Take the next day approximately 5 hours before the colonoscopy followed by at least three 8-ounce drinks of clear liquids before the colonoscopy; consume clear liquids within 5 hours up until 2 hours before the time of the colonoscopy. Preferred dosing method.

Condition: severe renal impairment (creatinine clearance less than 30 mL/minute)

Dose: Citric Acid Anhydrous + Magnesium Oxide + Sodium Picosulfate

Note: Contraindicated as accumulation of magnesium in plasma may occur

Condition: mild to moderate renal impairment

Dose: Citric Acid Anhydrous + Magnesium Oxide + Sodium Picosulfate

Note: Patients may be at increased risk for renal injury. Advise patients of the importance of adequate hydration before, during and after use. Consider performing baseline and post-colonoscopy laboratory tests (electrolytes, creatinine, and blood urea nitrogen) in these patients.