Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis B Age: Adult |
Dose: Oral Tablet – 10 mg Frequency: once daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis B Age: Child less than 12 years old |
Dose: Oral Note: Not recommended |
|
Indication: Chronic Hepatitis B Age: Child greater than 12 years old |
Dose: Oral – 10 mg Frequency: once daily Note: Administer as in adults; by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Haemodialysis patients |
Dose: 10 mg Frequency: every 7 days Note: administer after dialysis |
|
Condition: Creatinine Clearance 30-49 milliliters per minute |
Dose: 10 mg Frequency: every 48 hours |
Administration
- Take with or without food
- Take at same time each day
Side Effect
- Hematuria (11% vs 10% in placebo-treated)
- Asthenia (13% vs
- 14% placebo)
- Hepatitis exacerbation (25%)
- Nausea (5%)
- Flatulence (4%)
- Diarrhea (3%)Dyspepsia (3%)
- Headache (9%)
- Rash (1-10%)
- Pruritus (1-10%)
- Dyspepsia (5-9%)
- Cough (6-8%)
- Rhinitis (5%)
- Increased AST/ALT
- Abnormal liver function
- Renal failure
- Renal insufficiency
- Increased serum creatinine (2-3%)
- Hypophosphatemia
- Lactic acidosis
- severe hepatomegaly with steatosis
- hepatotoxicity
- nephrotoxicity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aminoglycosides, Ciclosporin, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Vancomycin, Tacrolimus
|
Increased risk of nephrotoxicity
|
|
Ibuprofen
|
Increases bioavailability of adefovir
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at cool and dry place. Protect from light and moisture. Keep all the medicines out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.