Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Partial-onset Seizures Condition: Initial Titration |
Dose: by mouth – 12.5 mg Frequency: once daily Duration: Weeks 1-2 Note: Indicated for treatment of partial-onset seizures as either monotherapy or adjunctive therapy. Do not exceed recommended dosage and titration, owing to potential for serious adverse reactions. |
|
Indication: Partial-onset Seizures Condition: Titration |
Dose: by mouth – 25 mg Frequency: once daily Duration: Weeks 3-4 |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: NO_HEADER – Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (Mild, moderate, or severe) |
Dose: Dosage Form with Dose – Not mentioned Note: Caution advised; consider dosage reduction |
|
Condition: End-stage renal disease |
Dose: Dosage Form with Dose – Not mentioned Note: Not recommended |
Administration
- Can be taken with or without food
- Swallow tablet whole with liquid
Side Effect
- Somnolence (up to 37%)
- Dizziness (up to 33%)
- Fatigue (up to 24%)
- Hyperkalemia (up to 17%)
- Diplopia (15%)
- Headache (up to 12%)
- Nausea
- Constipation
- Diarrhea
- Vomiting
- Dry mouth
- Abdominal pain
- Dyspepsia
- Nasopharyngitis
- Pharyngitis
- Urinary Tract Infection (UTI)
- Head injury
- ALT increased
- AST increased
- Weight decreased
- Decreased appetite
- Back pain
- Musculoskeletal chest pain
- Balance disorder
- Gait disturbance
- Dysarthria
- Nystagmus
- Ataxia
- Aphasia
- Vertigo
- Blurred vision
- Pollakiuria
- Dysmenorrhea
- Confusional state
- Euphoric mood
- Irritability
- Suicidal ideation
- Appendicitis
- DRESS
- Psychosis
- Hostility
- Aggression
- QT shortening
- Liver injury
- Suicidal behavior
- Hypersensitivity
- Manic disorder
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CNS depressants, alcohol
|
Increased risk of neurological adverse reactions
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Familial Short QT Syndrome (SQTS)
|
Risk of serious cardiac complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.