Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral Tablet – 8 mg Frequency: once daily Note: Initially 8 mg once daily, increased if necessary up to 32 mg once daily, doses to be increased at intervals of 4 weeks. Maintenance: 8 mg once daily. Maximum: 32 mg per day as single or in 2 divided doses. |
|
Indication: Hypertension Age: Adult Condition: Intravascular volume depletion |
Dose: Oral Tablet – 4 mg Frequency: once daily Note: Initially 4 mg once daily, increased if necessary up to 32 mg daily, doses to be increased at intervals of 4 weeks; usual dose 8 mg once daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: 1 to less than 6 years |
Dose: Oral – Initially, 200 mcg/kg/day Note: May increase according to response to 50-400 mcg/kg/day; All doses may be given as single or in 2 divided doses |
|
Indication: Hypertension Age: 6 to less than 17 years |
Dose: Oral – 4-8 mg/day Note: Adjusted according to response to 2-16 mg/day; All doses may be given as single or in 2 divided doses |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild renal impairment |
Dose: Form – Not specified Note: No dose adjustment necessary for patients with mild renal impairment |
|
Condition: Moderate renal impairment |
Dose: Form – Not specified Note: Initiate therapy at lower dose if moderate renal impairment |
Administration
- Can be taken with or without food
- Take at same time each day
Side Effect
- Dizziness
- headache
- vertigo
- back pain
- upper resp tract infections
- pharyngitis
- rhinitis
- hypotension
- hyperkalaemia
- increased serum creatinineeatinine
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
May reduce antihypertensive effect and deteriorate renal function
|
|
Lithium
|
May increase serum concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place. Protect from light and moisture
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.