Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Alzheimer Disease Condition: Moderate-to-severe, currently stabilized on donepezil 10 mg once daily |
Dose: Fixed dose combination product – 28 mg/10 mg Frequency: once daily Note: Administered by mouth (oral). Recommended dose is 28 mg/10 mg. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Dose: Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Stabilized on donepezil 10 mg/day and not currently on memantine |
Dose: Capsule – 7 mg/10 mg Frequency: once daily in the evening Note: Recommended starting dose; The dose should be increased to the recommended maintenance dose of 14 mg/10 mg once daily in the evening after a minimum of 1 week |
|
Condition: Stabilized on donepezil 10 mg/day and not currently on memantine |
Dose: Capsule – 14 mg/10 mg Frequency: once daily in the evening Note: Recommended maintenance dose; increase to this dose after a minimum of 1 week on starting dose |
Administration
- May take with or without food
- Can open capsule and sprinkle on applesauce
Side Effect
- Nausea (5-19%)
- Diarrhea (8-15%)
- Insomnia (5-14%)
- Accident (7-13%)
- Infection (11%)
- Dizziness (7%)
- Confusion (6%)
- Headache (6%)
- Constipation (5%)
- Cough (4%)
- Hypertension (4%)
- Backache (3%)
- Pain (3%)
- Somnolence (3%)
- Syncope (3%)
- Vomiting (3%)
- Dyspnea (2%)
- Fatigue (2%)
- Headache (4-10%)
- Vomiting (3-8%)
- Cramping (3-8%)
- Fatigue (3-8%)
- Anorexia (3-7%)
- Hypertension (3% )
- Abnormal dreams (3%)
- Hallucinations (3%)
- Confusion (2%)
- Syncope (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Urine Alkalinizing Agents (Sodium bicarbonate, Potassium citrate)
|
May alter effects of memantine
|
|
L-dopa, dopaminergic agonists
|
Enhanced effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.