Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ovarian carcinoma Age: Adult |
Dose: Intravenous – 1.5 mg/m2/day Frequency: once daily Duration: 5 days of a 21-day cycle Note: Min: 4 courses to be given (provided blood counts and haemoglobin have adequately recovered). Hepatic Impairment: Severe: Avoid. |
|
Indication: Small cell lung cancer Age: Adult |
Dose: Intravenous – 1.5 mg/m2/day Frequency: once daily Duration: 5 days of a 21-day cycle Note: Min: 4 courses to be given (provided blood counts and haemoglobin have adequately recovered). Hepatic Impairment: Severe: Avoid. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild Renal impairment (Creatinine Clearance 40-60 mL/min) |
Dose: Intravenous infusion – No dosage adjustment necessary Note: monotherapy |
|
Condition: Moderate Renal impairment (Creatinine Clearance 20-39 mL/min) |
Dose: by mouth – 0.75 mg/m² Frequency: once daily Note: monotherapy |
Administration
- Must be administered by healthcare professional
- Give as IV infusion over 30 minutes
Side Effect
- Neutropenia grade 4 (80%)
- Anemia grade 3 or 4 (41%)
- Thrombocytopenia grade 4 (27%)
- Febrile neutropenia (23%)
- Neutropenia grade 4 (70%)
- Anemia grade 3 or 4 (42%)
- Thrombocytopenia grade 4 (29%)
- Constitutional grade 3 or 4 (69%)
- Pain grade 3 or 4 (59%)
- Neutropenia grade 4 (48%)
- Vomiting grade 3 or 4 (40%)
- Anemia grade 3 (34%)
- Thrombocytopenia grade 3 (26%)
- Neutropenia grade 3 (26%)
- Nausea grade 3 or 4 (10%)
- Vomiting grade 3 or 4 (10%)
- Fatigue grade 3 or 4 (7%)
- Dyspnea grade 3 or 4 (6%)
- Diarrhea grade 3 or 4 (6%)
- Sepsis grade 3 or 4 (5%)
- Abdominal pain grade 3 or 4 (5%)
- Constipation grade 3 or 4 (5%)
- Intestinal obstruction grade 3 or 4 (5%)
- Asthenia grade 3 or 4 (5%)
- Pain grade 3 or 4 (5%)
- Neutropenia grade 4 (9%)
- Asthenia grade 3 or 4 (9%)
- Pneumonia grade 3 or 4 (8%)
- Nausea grade 3 or 4 (8%)
- Abdominal pain grade 3 or 4 (6%)
- Fatigue grade 3 or 4 (6%)
- Sepsis grade 3 or 4 (5%)
- Thrombocytopenia grade 4 (7%)
- Stomatitis-pharyngitis grade 3 or 4 (6%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenytoin
|
Increased clearance
|
|
G-CSF
|
Should be given 24 hr after completion of treatment with topotecan
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Unopened vial: Store at 20-25°C; protect from light. Reconstituted solution: Stable for 24 hr at 20-25°C in ambient light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.