Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Small cell lung cancer or Advanced ovarian carcinoma Age: Adult Condition: Single agent in treatment-naive patients |
Dose: Intravenous – 400 mg/m2 Note: Doses to be given not more frequently than every 4 weeks. Adjust subsequent doses based on nadir of white blood cell and platelet counts. |
|
Indication: Small cell lung cancer or Advanced ovarian carcinoma Age: Adult Condition: Single agent in previously treated patients |
Dose: Intravenous – 360 mg/m2 Note: Doses to be given not more frequently than every 4 weeks. Adjust subsequent doses based on nadir of white blood cell and platelet counts. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Solid tumor |
Dose: Intravenous – 300-600 mg/m² Frequency: every 4 weeks |
|
Indication: Sarcoma (bone/soft tissue) |
Dose: – 400 mg/m²/day Frequency: daily Duration: for 2 days every 21 days |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Intravenous – 250 mg/m² Frequency: On day 1 |
|
Condition: Renal Impairment |
Dose: Intravenous – 200 mg/m² Frequency: On day 1 |
Administration
- For hospital use only
- Must be administered by healthcare professional
Side Effect
- Leukopenia (26-97%)
- Neutropenia (21-96%)
- Nausea (81-93%)
- Vomiting (81-93%)
- Anemia (14-90%)
- Magnesium loss (43-61%)
- Thrombocytopenia (33-66%)
- Alopecia (2-49%)
- Asthenia (11-41%)
- Elevated alkaline phosphatase (29-37%)
- Central neurotoxicity (5-26%)
- Elevated AST (19-20%)
- Peripheral neuropathy (6-15%)
- Immune hypersensitivity reaction (2-9.2%)
- Elevated bilirubin (5%)
- Visual disturbance (rare)
- Bone marrow suppression and anaphylactic reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aminoglycosides
|
Increased risk of ototoxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Previous Allergy
|
Can cause life-threatening allergic reactions
|
|
Allergy to Other Platinum Compounds
|
Risk of severe cross-reactivity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.