Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Monotherapy or in combination with other anticonvulsants (Initial) |
Dose: Oral - 100-125 mg Frequency: once daily at bedtime Duration: for 3 days Note: Adult Oral Dose is individualised based on patient’s clinical response and tolerability. |
|
Age: Adult Condition: Monotherapy or in combination with other anticonvulsants (Titration Step 1) |
Dose: Oral - 100-125 mg Frequency: twice daily Duration: for 3 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Seizures (Psychomotor, Focal, & Grand Mal) |
Dose: Oral – 50 mg Frequency: once daily at bedtime Duration: for 3 days Note: initial by mouth (oral) |
|
Indication: Seizures (Psychomotor, Focal, & Grand Mal) |
Dose: Oral – 50 mg Frequency: twice daily Duration: for 3 days Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Renal Impairment – Dosage reduction may be required. Note: Dosage reduction may be required. |
Administration
- May be taken with or without food
- Take with food if stomach upset occurs
Side Effect
- Dysarthria
- Paresthesia
- Ataxia
- Vertigo
- Pediatric patients
- Paradoxical excitement
- Hyperactivity
- Geriatric patients
- Excitement
- Confusion
- Depression
- Drowsiness
- Ataxia
- Irritability
- Headache
- Restlessness
- Nystagmus
- Dizziness
- Vertigo
- Acute psychosis (rare)
- Nausea
- Vomiting
- Constipation
- Diarrhea
- Megaloblastic (folate-deficiency) anemia
- Hepatotoxicity
- Hypocalcemia
- Rickets (rare)
- Osteomalacia (rare)
- Rash
- Stevens-Johnson syndrome (rare)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inhibitors (e.g. chloramphenicol, felbamate, nelfinavir, metronidazole, Na valproate)
|
May increase serum concentration
|
|
Various drugs (e.g. androgens, β-antagonists, carbamazepine, chloramphenicol, clozapine, Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), cyclophosphamide, cyclosporin, dicoumarins, digitoxin, doxycycline, ethosuximide, etoposide, felbamate, granisetron, lamotrigine, losartan, methadone, metronidazole, mianserin, montelukast, nelfinavir, nimodipine, oral contraceptives, oxcarbazepine, phenytoin, quinidine, rocuronium, Na valproate, tiagabine, theophylline, topiramate, TCAs, vecuronium, warfarin, zonisamide)
|
May increase metabolism resulting in lower serum concentration and shorter half-life
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.