Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Insomnia Age: Adult Condition: Short-term treatment (maximum 2 weeks) of severe insomnia which is interfering with normal daily life and where other therapies (behavioural and pharmacologic) have failed |
Dose: Oral Solution – 430-860 mg (15-30 ml of the 143mg/5ml strength) Note: Higher doses should not exceed a maximum of 2 g chloral hydrate (70 ml of the 143mg/5ml strength) per dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Severe insomnia Age: Children 12 years and over Condition: Interfering with normal daily life and other therapies (behavioural and pharmacologic) have failed |
Dose: Oral – 430-860 mg (15-30 ml of the 143mg/5ml strength) Duration: maximum 2 weeks Note: Short-term treatment in children and adolescents with suspected or definite neurodevelopmental disorder. Higher doses should not exceed a maximum of 2 g chloral hydrate (70 ml of the 143mg/5ml strength) per dose. |
|
Indication: Severe insomnia Age: Children (between 2 and 11 years) Condition: Interfering with normal daily life and other therapies (behavioural and pharmacologic) have failed |
Dose: Oral – 1-1.75 ml/kg of the 143mg/5ml strength Duration: maximum 2 weeks Note: Short-term treatment in children and adolescents with suspected or definite neurodevelopmental disorder. The dose should not exceed 1 g chloral hydrate (35 ml of the 143 mg/5ml strength) per dose. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Renal Dose Note: Contraindicated in moderate-severe renal impairment |
Administration
- Dilute with water or fruit juice
- Take at regular intervals
Side Effect
- Significant Gastric irritation (eg nausea, vomiting, diarrhoea)
- abdominal distention
- flatulence
- tolerance
- dependence
- Nervous Drowsiness
- light-headedness
- headache
- paradoxical excitement
- hallucination
- nightmares
- confusion
- ataxia
- GI Gastritis
- unpleasant taste
- Genitourinary Ketonuria
- parenchymatous renal injury
- Dermatologic Erythema multiforme
- Stevens-Johnson syndrome
- Delirium tremens
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Opiates, barbiturates, TCAs, Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), other sedatives
|
Enhanced sedative effect
|
|
IV furosemide
|
May cause hot flushes, sweating, and HTN
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.