Pranlukast hydrate is administered orally as a capsule or dry syrup. It should be taken twice daily, typically after breakfast and after the evening meal. The capsules should be swallowed whole with water, while the dry syrup should be suspended in water immediately before administration. No specific dose adjustments are strictly required for mild renal or hepatic impairment, but caution is advised in severe hepatic impairment. Precautions include monitoring for rare but severe cases of Churg-Strauss syndrome, presenting as systemic eosinophilia and vasculitis, particularly when systemic corticosteroids are being reduced. It is widely used in pediatric populations with appropriate age- or weight-based dosing formulations. Elderly patients generally require no specific dose adjustments but should be monitored for potential hepatic or systemic adverse events.

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