Indication
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Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acutely decompensated heart failure Age: Adult |
Dose: Intravenous – Loading dose: 6-12 mcg/kg Frequency: infusion over 10 minutes Note: Dose and duration of treatment are individualised according to the patient’s clinical condition and response. Hepatic Impairment Severe: Contraindicated. |
|
Indication: Acutely decompensated heart failure Age: Adult |
Dose: Intravenous – Maintenance: 0.1 mcg/kg/min Frequency: continuous infusion Note: May decrease to 0.05 mcg/kg/min if significant hypotension or tachycardia occur or may increase to 0.2 mcg/kg/min if the initial dose is tolerated and an increased haemodynamic effect is required. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Dosage - Not provided Note: Contraindicated |
Administration
Levosimendan is administered via continuous intravenous infusion, preferably through a central venous catheter. The concentrate must be diluted in 5% glucose prior to use to a final concentration of 0.05 mg/mL. An optional loading dose of 6 to 12 micrograms/kg may be infused over 10 minutes, followed by a maintenance infusion of 0.1 micrograms/kg/min, adjustable between 0.05 and 0.2 micrograms/kg/min based on hemodynamic response and tolerability for up to 24 hours. Monitor blood pressure, heart rate, and electrolytes during and for several days after infusion. It is contraindicated in severe renal or hepatic impairment and severe hypotension. Use with caution in pediatric populations and patients with mild to moderate renal or hepatic impairment.
Side Effect
- Hypokalaemia, decreased Hb and haematocrit, ventricular tachycardia, atrial fibrillation, ventricular extrasystoles, hypotension
- Myocardial ischaemia, cardiac failure
- Diarrhoea, constipation, nausea, vomiting
- Headache, dizziness
- Insomnia
Drug Interaction
Drug Interaction
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Disease Interaction
Disease Interaction
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Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
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Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.